BRM4 500MG 60 Capsules
BY Daiwa Health Developement
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Daiwa Health Development Introduces Double Strength BRM4™ Rice Bran Arabinoxylan Compound
(Los Angeles, CA) November 17, 2008 – Daiwa Health Development has introduced double strength BRM4™, a 500mg, 60 count version of its patented immune enhancing complex to the health professional marketplace. BRM4™, with its active ingredient Rice Bran Arabinoxylan Compound (RBAC), has been clinically shown to triple Natural Killer (NK) cell activity, increase T and B lymphocytes and demonstrate vital antioxidant and anti-inflammatory action.RBAC, a polysaccharide dietary fiber derived from rice bran, is modified by a Shiitake mushroom enzyme using a patented biotechnology process. As an immune modulator, BRM4™ retains its effectiveness over time. Clinical trials have shown BRM4 is safe with no side effects. In over 12 years of worldwide use, there have been no reported cases of drug interactions. BRM4™ is recognized as the gold standard immune product worldwide for people with seriously compromised immune systems.BRM4™ in a 250mg dosage, 60 count bottle, has been available through physicians for over 10 years. In pre-clinical studies, the power of BRM4™ multiplies T cell levels up to 200%. The enhanced activity of helper T cells promotes the proliferation of cytotoxic T and B cells for essential immune support. Helper T cells also signal plasma B cells when they encounter their cognate antigen to secure a health production of antibodies. Furthermore, BRM4™ supports the body’s natural production of cytokines to control inflammatory response. Double Strength BRM4™ is now available to health professionals in the U.S. For more product and ordering information call 877.434.3633 or email [email protected] Los Angeles-based Daiwa Health Development, Inc. is a subsidiary of Daiwa Pharmaceutical Co. Ltd. based in Tokyo, Japan. Daiwa has become a leading research and manufacturing company, striving to create new value in the field of bioscience. Daiwa focuses on the manufacturing and distribution of nutraceuticals, functional foods and cosmetics.
What is BRM4?
A Biological Response Modifier (BRM) An Immunomodulator
Benefits of BRM4 Immunomodulation
Maintains Strong Immune System
Safe Over Prolonged Period of Time
Does not cause hyper-response of immune system
Does not lose efficacywith prolonged use
Low Maintenance Dose
How Does BRM4 Work?
Elevates Immune Activity to Match the Challenges of Todays Environment
Augments (3x) Natural Killer cell activity
Increases B- &T-Cell Counts (both helper &cytotoxic T cells)
Anti-inflammatory &Antioxidant action
Supports Healthy Cytokine Activity levels
Who needs BRM4?
People with Immune System Decline or Suppression due to Aging (e.g., over 45)
Poor Nutrition/Dietary Habits, or Illness
Individuals interested in prevention due to family history
People with chronic toxic fume or chemical exposure history (e.g., factory workers, military, large cities, etc.)
Anyone desiring to maintain a strong immune system
BRM4-BioBran is a functional food manufactured using a water-soluble rice bran dietary fiber component (hemicellulose B). Collaborative research with Prof. Mamdooh Ghoneum PhD at the University of California, Los Angeles, USA(UCLA/Drew University of Medicine and Science) on rice bran dietary fiber components has led to the discovery and establishment of processing and manufacturing methods of a food that optimally modulates the innate function of the body. It was subsequently demonstrated that BioBran has not only an immunostimulatory effect but also an immunomodulating effect. Extensive efforts to maximize its stability and taste have resulted in BioBran rice bran arabinoxylan. Currently, BioBran is widely used not only in Japan but also in 49 countries worldwide, and has an excellent reputation.
※Patents (Immunopotentiator and method of manufacturing the same): Japan No.3519187, U.S.A. No.5560914, UK, France, Spain, Italy, Germany, and Portugal No.753582, South Korea No.0344755
Bio Bran- Development Back Ground
The condition of the body is maintained at a constant level by modulating body temperature and blood pressure, to cope with changes in the environment inside and outside the body.
This mechanism is called homeostasis. In homeostasis, the innate immune system plays an important role: it eliminates foreign substances (non-self) such as pathogens, viruses and cancer cells. However, it is known that immune function deteriorates with aging, and is impaired or stimulated by a poor lifestyle such as smoking, insufficient physical exertion or an unbalanced diet, and by adverse environmental changes and pollution.
Deterioration of immune function causes or aggravates infection and malignant tumors, while excessive elevation of the immune system may cause things such as hay fever, atopic dermatitis or chronic inflammation.
Daiwa Pharmaceutical Co., Ltd. has focused on a dietary fiber thought to have the potential to impact the immune response and developed a multifunctional food slosely related to the Japanese foodstuff of ancient times, named BioBran (Rice Bran Arabinoxylan Compound).
Bio Bran Mechanism of Action
Starch, dietary fiber, and BioBran are classified as polysaccharides. Starch is digested by saliva, pancreatic juice, and intestinal juice, and is absorbed in the small intestine as glucose. Dietary fiber is not digested, and is excreted unchanged. BioBran is known to be partly absorbed directly in the digestive tract, entering the blood stream.
It activates the Natural Killer Cells, T cells, B cells, and macrophages, either directly in the blood, or indirectly via the Peyer’s patch of the ileum, BioBran plays an important role in immunomodulation (immunostimulation, anti-inflammation, anti-allergy, antioxidation processes). Overall, it is considered to enhance the body’s natural healing abilities, alleviate the adverse drug reactions of chemotherapeutic agents, and improve quality of life.
① Response of human NK cell activation to dose of BioBran
② NK cell activation in cancer patients following BioBran intake
③ Stimulation of lymphocyte transformation
④ Promotion of differentiation of dendritic cells
⑤ Anticancer effect of BioBran
Influence on liver damage
Combination Therapy with a chemotherapeutic Agent – BIOBRAN
BioBran in combination with a chemotherapeutic agent
Improvement of Quiality of Life – BIOBRAN
Effect of BioBran on survival and quality of life improvement in patients with progressive cancer
Bio Bran Specifications
Test items Specification
Description Light-brown powder
Arsenic (as AS2O3) ≦5ppm
Heavy metal (as Pb) ≦20ppm
Total viable count ≦3×103 CFU/g
Coliform bacteria Negative